. Author manuscript; available in PMC: 2014 Mar 22.

Published in final edited form as: Growth Factors. 2012 Jan 20;30(2):107–116. doi: 10.3109/08977194.2011.649918

Table I.

EGF ligands differentially stimulate EGFR coupling to cell proliferation and DNA synthesis

	Cell proliferation 32D/EGFR cells			DNA synthesis MCF10A cells
Ligand	EC₅₀ (nM)	E_max (cell density × 10⁴)	N	EC₅₀ (nM)	E_max (% complete media)	N
AR	10 ± 3	45 ± 3	4	18 ± 4	98 ± 6	3
BTC	0.18 ± 0.07	10.3 ± 0.8	4
EGF	0.24 ± 0.09	11.8 ± 0.7	5	0.7 ± 0.2	70 ± 4	6
EPG	1.7 ± 0.7	42 ± 4	3
EPR	0.6 ± 0.2	30 ± 2	4
HB-EGF	1.0 ± 0.4	16 ± 1	3	1.5 ± 0.5	64 ± 5	4
NRG2β	16 ± 3	53 ± 2	12
TGFα	37 ± 8	69 ± 4	4	2.7 ± 0.9	93 ± 6	4