. Author manuscript; available in PMC: 2014 Mar 22.

Published in final edited form as: Cancer Causes Control. 2010 Jan 19;21(5):745–757. doi: 10.1007/s10552-010-9503-z

Table 3.

Unadjusted and multivariate-adjusted odds ratios and 95% confidence intervals for arsenic in drinking water and bladder cancer, Southeastern Michigan, Enrolled 2002–2006

	Unadjusted analyses				Multivariate-adjusted analyses^a

	Cases (no.)	Controls (no.)	OR	95% CI	Cases^b (no.)	Controls^b (no.)	OR	95% CI
Arsenic concentration in water (TWA)
Continuous (per 5 µg/L increase)	411	566	1.11	0.98, 1.25	407	564	1.05	0.92, 1.20
Categorical
<1 µg/L	188	264	1.00		187	264	1.00
1–10 µg/L	185	263	0.99	0.76, 1.29	182	180	0.84	0.63, 1.12
>10 µg/L	38	39	1.37	0.84, 2.22	38	37	1.10	0.65, 1.86
Arsenic intake from water (TWA)^c
Continuous (per 5 µg/day increase)	398	536	1.06	0.97, 1.17	394	534	1.01	0.92, 1.12
Categorical
<1 µg/day	190	254	1.00		189	252	1.00
1–10 µg/day	165	234	0.99	0.75, 1.29	162	234	0.83	0.62, 1.11
>10 µg/day	43	48	1.25	0.80, 1.96	43	48	1.01	0.62, 1.64

OR odds ratio; CI confidence interval; TWA time-weighted average life-course exposure estimate

Adjusted for cigarette smoking history, education, history of employment in high-risk occupation, family history of bladder cancer, age, race, and sex

Differences in numbers of cases and controls in adjusted analyses attributable to missing pack-year data from six participants

Differences in numbers of cases and controls for arsenic intake metric attributable to missing water consumption data