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. 2014 Jan 14;306(7):E723–E739. doi: 10.1152/ajpendo.00326.2013

Table 3.

Voluntary wheel running exercise performance of MuRF1+/+ and MuRF1−/− mice

Week 1 Week 2 Week 3 Week 4 Week 5 Overall (Weeks 1–5)
Running time, min/day
    MuRF1+/+ 329.8 ± 28.8 348.4 ± 18.5 323.0 ± 25.4 359.8 ± 19.3 341.3 ± 16.3 343.1 ± 14.8
    MuRF1−/− 349.9 ± 28.8 375.5 ± 24.6 325.1 ± 24.3 384.5 ± 17.0 382.3 ± 31.1 363.7 ± 18.7
Speed, mph
    MuRF1+/+ 2.80 ± 0.199 3.30 ± 0.161 3.31 ± 0.171 3.59 ± 0.146 3.64 ± 0.169 3.31 ± 0.142
    MuRF1−/− 3.46 ± 0.224* 4.84 ± 1.71 4.52 ± 0.303* 4.92 ± 0.256# 4.92 ± 0.407* 4.47 ± 0.279*
Distance, km
    MuRF1+/+ 10.1 ± 1.2 12.2 ± 0.93 11.2 ± 0.96 13.9 ± 0.87 13.1 ± 0.91 12.1 ± 0.73
    MuRF1−/− 13.0 ± 1.7 19.0 ± 2.1* 15.6 ± 1.83* 19.5 ± 1.32* 19.9 ± 2.5* 17.2 ± 1.5*

Data are expressed as means ± SE. MuRF1+/+, n = 8–9/wk; MuRF1−/−, n = 8/wk. Rarely, mice stopped running and were excluded from further study (preventing a repeated-measures statistical analysis). Student's t-test was performed to compare MuRF1−/− with WT control animals.

*

P ≤ 0.05;

#

P < 0.001 MuRF1+/+ vs. MuRF1−/−.