Table 4.
Voluntary wheel running exercise performance of WTMuRF1 Tg+ and MuRF1Tg+ mice
| Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Overall (Weeks 1–5) | |
|---|---|---|---|---|---|---|
| Running time, min/day | ||||||
| WTMuRF1Tg+ | 419.4 ± 19.0 | 383.0 ± 31.2 | 332.5 ± 26.1 | 309.4 ± 38.4 | 324.4 ± 37.5 | 357.0 ± 20.0 |
| MuRF1Tg+ | 387.9 ± 35.1 | 361.9 ± 35.8 | 351.7 ± 31.7 | 342.2 ± 38.8 | 378.7 ± 51.8 | 366.2 ± 32.5 |
| Speed, mph | ||||||
| WTMuRF1Tg+ | 3.20 ± 0.179 | 4.29 ± 0.188 | 3.92 ± 0.197 | 3.83 ± 0.146 | 4.29 ± 0.216 | 3.87 ± 0.141 |
| MuRF1Tg+ | 3.38 ± 0.177 | 4.14 ± 0.281 | 4.36 ± 0.373 | 4.13 ± 0.417 | 4.50 ± 0.298 | 4.09 ± 0.286 |
| Distance, km | ||||||
| WTMuRF1Tg+ | 14.0 ± 0.82 | 17.6 ± 1.6 | 14.1 ± 1.6 | 12.5 ± 1.8 | 14.9 ± 2.3 | 14.5 ± 1.1 |
| MuRF1Tg+ | 14.0 ± 1.2 | 15.8 ± 1.1 | 15.8 ± 1.6 | 15.6 ± 2.7 | 17.2 ± 2.1 | 15.7 ± 1.4 |
Data are expressed as means ± SE. WTMuRF1Tg+, n = 6–8/wk; MuRF1Tg+, n = 7/wk. Rarely, mice stopped running and were excluded from further study (preventing a repeated-measures statistical analysis). Student's t-test was performed to compare MuRF1−/− with WT control animals. No differences between groups were identified (P > 0.05).