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. 2014 Jan 28;306(7):E756–E768. doi: 10.1152/ajpendo.00549.2013

Fig. 10.

Fig. 10.

Pharmacological inhibition of SK1 ameliorates inflammatory responses in adipocytes and adipose SVF cells. TNFα (A), IL-6 (B), MCP-1 (C), SOCS3 (D), IL-10 (E), and adiponectin (F) mRNA levels in adipocytes isolated from EAT of DIO mice treated daily for 3 days with the specific SK1 inhibitor 5c (2 mg/kg ip) or with vehicle control. TNFα (G), IL-6 (H), MCP-1 (I), and IL-10 (J) mRNA levels in SVF cells from control and 5c-treated mice as above; n = 6 ± SD. *P < 0.05 and **P < 0.01, 5c vs. control.