Fig. 8.

A: basal cGMP levels in aortas of WT littermates and ePPARδ^−/− mice (n = 9–11). B: effects of in vitro incubation with catalase (1,400 U/ml) on cGMP levels in ePPARδ^−/− mouse aortas (n = 6). C: effects of H₂O₂ (100 μmol/l) on cGMP levels in WT mouse aortas in the absence or presence of the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ; 10 μmol/l, n = 5). D: effects of endothelium removal (E−) on cGMP levels in WT mouse aortas in the presence or absence of H₂O₂ (100 μmol/l; n = 7). All results were normalized against tissue protein levels. *P < 0.05 vs. WT mice; † P < 0.05 vs. control ePPARδ^−/− mice; #P < 0.05 vs. H₂O₂.