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Three-dimensional chemical structures of the LNA heptanucleotides (A) 5′-ATGTAGC-3′ and (B) 5′-ATGAAGC-3′. The 5′ end is placed to the right. The topology of the electrostatic potentials of the two heptanucleotides is shown in (C) 5′-ATGTAGC-3′ and (D) 5′-ATGAAGC-3′. The energy of the electrostatic iso-potential surfaces is set to 1.63 eV (157 kJ/mol). The negative potential is marked with red and the positive with yellow. The 5′ end is to the right.
