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AptamiRs. AptamiRs were generated by extending the aptamer AS1411 at the 3′ end with three thymidine nucleotides followed by a phosphorothiolated (PTO) antimiR locked nucleic acid (LNA) oligonucleotide sequence targeting the micro RNA miR-21 (a and b). As control molecules AptamiR variants with either a nonfunctional LNA moiety (c, e) or nontargeting control sequence (d, e) were synthesized.
