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. Author manuscript; available in PMC: 2014 Aug 24.
Published in final edited form as: Nat Commun. 2014;5:3349. doi: 10.1038/ncomms4349

Figure 3. Selective DHA inhibition of fully edited chimaeric receptors.

Figure 3

Whole-cell current evoked by 10 μM NMDA and 10 μM glycine (open bars) at −80 mV before and after exposure to 30 μM DHA (solid bar) in a cell transfected with fully edited N1/K2(R) + N2B/K2(R) subunits (a) and in a cell that received N1/K2(Q)+N2B/K2(R) (b). (c) Plot of current evoked immediately after exposure to DHA as a fraction of control current before DHA (mean ± s.e.m.) for the 4 chimaeric combinations and, for comparison, wild type homomeric GluK2(Q) and (R) and heteromeric GluK2(R)+GluK5(Q). Sample size is shown for each bar. * significantly different from N1/K2(Q)+N2B/K2(Q) and homomeric GluK2(Q) (P < 0.0001, one way ANOVA with post hoc Student-Newman-Keuls comparison).