Table 2.

Genotypic association analysis between rs2043211 and ischemic stroke.

Cohorts	Model	Case(n)	Control(n)	P-obs	P-adj	OR(95%CI)
GenelD-Central IS (903/873)
	Additive	173/521/209	230/430/213	2.88E-04	0.082	0.83(0.67-1.02)
	Dominant	694/209	660/213	0.535	0.520	1.12(0.80-1.56)
	Recessive	173/730	230/643	3.00E-04	0.028	0.68(0.48-0.96)
GenelD-North IS (816/879)
	Additive	174/464/178	235/404/240	4.26E-05	0.692	0.97(0.81-1.15)
	Dominant	638/178	639/240	0.009	0.085	1.28(0.97-1.69)
	Recessive	174/642	235/644	0.009	0.017	0.70(0.53-0.94)
Combined IS (1719/1752)
entire cohort	Additive	347/985/387	465/834/453	3.13E-08	0.324	0.94(0.83-1.06)
entire cohort	Dominant	1332/387	1299/453	0.021	0.075	1.19(0.98-1.45)
entire cohort	Recessive	347/1372	465/1287	9.78E-06	5.83E-04	0.70(0.57-0.86)
Female	Recessive	127/561	203/563	2.57E-04	0.007	0.65(0.48-0.89)
Male	Recessive	220/811	262/724	0.006	0.024	0.73(0.56-0.96)
Age<60	Recessive	104/442	360/965	2.17E-04	0.001	0.61(0.45-0.83)
Age≥60	Recessive	243/930	105/322	0.100	0.107	0.79(0.59-1.05)
Female and Age<60	Recessive	43/206	155/421	0.003	0.004	0.51(0.32-0.80)
Male and Age<60	Recessive	61/236	205/544	0.022	0.104	0.71(0.48-1.08)

Model: Additive(TT/AT/AA), Dominant(TT+AT/AA),Recessive(TT/AT+AA); OR, odds ratio;

P-ohs, P value using 2 × 2 contingency table χ2 tests before adjustment for covariates;

P-adj, P value adjusted by multivariate logistic regression analysis for traditional risk factors, including age, sex, BMI, smoking history, hypertension, DM, TC, TG, HDL- and LDL-C)