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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Mol Cancer Res. 2014 Jan 10;12(3):381–393. doi: 10.1158/1541-7786.MCR-13-0480

Fig. 7. Proposed model for impairment of HRR by triapine in EOC cells.

Fig. 7

Triapine causes depletion of dNTPs and activation of Chk1, which in turn blocks CDK-mediated phosphorylation of CtIP. As a result, CtIP-mediated resection of DSBs caused by PARP and topoisomerase II inhibitor is abrogated, leading to impairment of HRR.