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The SphK1/2 activity in APP-transfected cells. The activity of SphK(s) was determined spectrofluorimetically with NBD-Sphingosine as described in “Materials and Methods” section. Data represent the mean value ± SEM for six independent experiments carried out in triplicate. ***p < 0.001 versus PC12 cells; # p < 0.05 versus APPwt cells using a one-way ANOVA followed by Bonferroni’s Multiple Comparison Test
