Fig. 4.
Effect of S1P on SKI II-evoked decrease in cell viability. PC12 and APP-transfected cells were pre-incubated with 1 µM S1P for 5 min, and then 10 µM SKI II was added for 24 h. Cell viability was spectrophotometrically determined using the MTT assay. Data represent the mean value ± SEM for three separate experiments carried out in triplicate. *p < 0.05 versus non-treated APPsw cells; ***p < 0.001 versus corresponding control; ## p < 0.01 versus SKI II-treated PC12 cells; $ p < 0.05 versus SKI II-treated APPwt cells, using one-way ANOVA followed by Bonferroni’s Multiple Comparison Test