Table 4.
Prognostic factors of on-study SRE
| N | Odds ratio (95 % CI) | p value | |
|---|---|---|---|
| Univariate analyses | |||
| Weight | 71 | 1.01 (0.97, 1.06) | 0.60 |
| Height | 71 | 1.00 (0.89, 1.12) | 0.95 |
| BSA | 71 | 2.57 (0.05, 143.61) | 0.65 |
| Duration of bone metastases | 70 | 1.02 (0.99, 1.04) | 0.24 |
| PTH | 71 | 1.05 (0.99, 1.12) | 0.12 |
| Vitamin D (/10 units) | 71 | 0.97 (0.80, 1.17) | 0.75 |
| FACT-BP Subscale | 71 | 0.99 (0.93, 1.05) | 0.66 |
| Baseline CTx (/10 units) | 71 | 1.01 (0.97, 1.04) | 0.70 |
| BSAP | 70 | 0.99 (0.88, 1.12) | 0.85 |
| NTx (/100 units) | 63 | 0.98 (0.77, 1.25) | 0.86 |
| P1NP (/1,000 units) | 63 | 1.02 (0.99, 1.04) | 0.27 |
| BSP (/10 units) | 63 | 1.07 (0.97, 1.19) | 0.19 |
| TGF-β | 63 | 0.88 (0.76, 1.03) | 0.11 |
| Activin A (/100 units) | 63 | 0.98 (0.89, 1.08) | 0.73 |
| BPI-severity | 70 | 1.15 (1.03, 1.28) | 0.017 |
| BPI-interference | 69 | 1.04 (0.99, 1.10) | 0.11 |
| Metastatic disease (bone only vs bone plus other) | 65 | 0.40 (0.09, 1.78) | 0.23 |
| Prior SRE (ordinal) | 71 | 1.18 (0.52, 2.70) | 0.70 |
| Prior SRE (≥1 vs none) | 71 | 1.71 (0.38, 7.75) | 0.48 |
| Multivariate analyses | |||
| BPI-Severity | 70 | 1.15 (1.03, 1.28) | 0.017 |
Results for the prognostic ability of various factors for a patient having at least one SRE. BPI-severity score was the only factor statistically significant in the univariate or multivariate analyses