Table 1.

Positive sera against centromere protein (CENP)-P and -Q in systemic sclerosis (SSc) and other cohorts. Positives to CENP-P/-Q were determined by ELISA and Western blot methods. P value was calculated using Pearson’s chi-square or Fisher’s exact test. P values < 0.05 are shown in bold type, indicating statistically significant differences compared to anticentromere antibody (ACA)-positive.

		Anti-CENP-P (+)	Anti-CENP-Q (+)
Cohort	Cases	No. (%, p value)	No. (%, p value)
SSc
ACA+	35	14 (40)	11 (31.4)
ACA‒	151	9 (6, < 0.0001)	0 (0, < 0.0001)
pSS (ACA+)	18	1 (5.6, 0.0207)	2 (11.1, 0.1771)
SLE (ACA+)	20	3 (15, 0.1038)	5 (25, 0.7608)
RA (ACA+)	13	2 (15.4, 0.1703)	0 (0, 0.0228)
PBC (ACA+)	18	5 (27.8, 0.5644)	1 (5.6, 0.0412)
Healthy (ACA‒)	31	0 (0, 0.0002)	0 (0, 0.0020)

SLE: systemic lupus erythematosus; pSS: primary Sjögren syndrome; RA: rheumatoid arthritis; PBC: primary biliary cirrhosis.