Table 2.
Association analysis between anti-CENP-P antibody in systemic sclerosis (SSc) sera and clinical manifestations and laboratory features. Bold type indicates p values < 0.05, considered statistically significant. Data are percentages unless indicated otherwise.
| ACA (+) | ACA (−) | All | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Anti-CENP-P | + | − | p* | + | − | p* | + | − | p* |
| No. Cases | 14 | 21 | 9 | 142 | 23 | 163 | |||
| Disease pattern, limited/diffuse | 12/2 | 17/4 | 1.0000 | 4/5 | 70/72 | 1.0000 | 16/7 | 87.76 | 0.2156 |
| Sex, men/women | 1/13 | 1/20 | 1.0000 | 0/9 | 13/129 | 1.0000 | 1/22 | 14/149 | 0.6983 |
| Age, mean SD, yrs | 50.9 ± 13.6 | 45.5 ± 7.8 | 0.1461 | 48.4 ± 14.0 | 43.6 ± 12.5 | 0.2653 | 49.9 ± 13.5 | 43.8 ± 12 | 0.0267 |
| Anti-CENP-B | 100 | 95.20 | 1.0000 | 0.0 | 0.0 | 1.0000 | 60.9 | 12.3 | < 0.0001 |
| Anti-CENP-A | 92.90 | 90.50 | 1.0000 | 0.0 | 0.0 | 1.0000 | 56.5 | 11.7 | < 0.0001 |
| Anti-Scl-70 | 14.30 | 9.50 | 1.0000 | 44.4 | 52.1 | 0.7395 | 26.1 | 46.6 | 0.1025 |
| Raynaud phenomenon | 100 | 95.20 | 1.0000 | 100 | 94.4 | 1.0000 | 100.0 | 94.5 | 0.6042 |
| Arthralgia/arthritis | 35.70 | 33.30 | 1.0000 | 77.8 | 55.6 | 0.3010 | 52.2 | 52.8 | 0.8648 |
| Digital ulcers | 21.40 | 19 | 1.0000 | 22.2 | 29.6 | 1.0000 | 21.7 | 28.2 | 0.6872 |
| Muscle weakness | 21.40 | 19 | 1.0000 | 33.3 | 32.4 | 1.0000 | 26.1 | 30.7 | 0.8366 |
| Gastrointestinal manifestations | 14.30 | 4.80 | 0.5508 | 22.2 | 22.5 | 1.0000 | 17.4 | 20.2 | 1.0000 |
| Cardiac involvement | 7.10 | 9.50 | 1.0000 | 22.2 | 7.7 | 0.1745 | 13.0 | 8.0 | 0.4245 |
| Renal crisis | 7.10 | 0 | 0.4000 | 0.0 | 2.1 | 1.0000 | 4.3 | 1.8 | 0.4129 |
| Kidney involvement | 7.10 | 0 | 0.4000 | 22.2 | 2.8 | 0.0420 | 13.0 | 2.5 | 0.0418 |
| Lung involvement | 0 | 4.80 | 1.0000 | 44.4 | 21.1 | 0.1159 | 17.4 | 19.0 | 1.0000 |
| Interstitial lung disease | 28.60 | 33.30 | 1.0000 | 77.8 | 79.6 | 1.0000 | 47.8 | 73.6 | 0.0218 |
| Pulmonary arterial hypertension | 0 | 9.50 | 0.5059 | 33.3 | 17.6 | 0.3687 | 13.0 | 16.6 | 1.0000 |
| IgG, mean SD g/l | 16.7 ± 6 | 13.3 ± 2.9 | 0.0463 | 18.3 ± 5 | 16.7 ± 6.6 | 0.5238 | 17.3 ± 5.6 | 16.3 ± 6.3 | 0.5185 |
| IgA, mean SD g/l | 3 ± 1.3 | 2.2 ± 0.8 | 0.0288 | 2.4 ± 0.8 | 2.8 ± 1.3 | 0.4032 | 2.8 ± 1.2 | 2.7 ± 1.3 | 0.7055 |
| IgM, mean SD g/l | 1.8 ± 1 | 1.6 ± 1 | 0.7164 | 1.2 ± 0.3 | 1.4 ± 0.7 | 0.5531 | 1.6 ± 0.9 | 1.4 ± 0.7 | 0.3272 |
| ESR, mean SD mm/h | 25.9 ± 20.2 | 10.1 ± 9.2 | 0.0075 | 25.3 ± 15.3 | 24.4 ± 26.1 | 0.9238 | 25.7 ± 18.2 | 22.7 ± 25 | 0.5863 |
*
P values calculated using Pearson’s chi-square or Fisher’s exact test and 2-tailed T-test if necessary.
CENP: centromere protein; ESR: erythrocyte sedimentation rate; ACA: anticentromere antibodies.