Table 1.
Cox Proportional Hazards Model for Progression Free Survival (Patients who received irradiation as part of the primary treatment were censored at time of irradiation)
| Variables | Univariate Analyses | Multivariate Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| HR1 | 95% CI1 | p1 | HR2 | 95% CI2 | p2 | HR3 | 95% CI3 | p3 | |
| Age at Diagnosis | |||||||||
| Relative risk increase per 1 year | 1.2 | (1.05, 1.4) | 0.017 | 1.0 | (0.84, 1.3) | 0.78 | Not included in the model | ||
| >=3 year vs. <3 year | 3.5 | (1.3, 9.1) | 1.2 | (0.36, 3.8) | |||||
|
| |||||||||
| Stage4 | |||||||||
| M0 | 1.0 | -- | 0.006 | 1.0 | -- | 0.004 | 1.0 | -- | 0.002 |
| M+ | 4.7 | (1.4, 15) | 16 | (2.0, 128) | 7.9 | (1.8, 34) | |||
|
| |||||||||
| Histology4 | |||||||||
| Classic | 1.0 | -- | 0.21 | 1.0 | -- | 0.27 | |||
| Desmoplastic/nodular | 0.42 | (0.09, 2.0) | 3.8 | (0.29, 49) | Not included in the model | ||||
| Anaplastic/Large Cell | 2.0 | (0.54, 7.6) | 0.35 | (0.06, 1.9) | |||||
|
| |||||||||
| Molecular Subgroup4 | |||||||||
| SHH/WNT | 1.0 | -- | 0.048 | 1.0 | -- | 0.75 | |||
| Group 3 | 6.2 | (1.5, 26) | 2.7 | (0.17, 44) | Not included in the model | ||||
| Group 4 | 3.2 | (0.58, 18) | 2.1 | (0.12, 37) | |||||
|
| |||||||||
| PID1 | |||||||||
| High | 1.0 | -- | 1.0 | -- | 1.0 | -- | |||
| Low | 6.8 | (2.2, 21) | <0.001 | 21 | (1.9, 221) | 0.005 | 12.1 | (2.8, 52) | <0.001 |
Abbreviations: HR, hazard ratio; CI, confidence interval.
1
HR and CI from univariate Cox models.
2
HR, CI and p-values from the Cox model that included age, stage, histology, molecular subgroup and PID1 expression.
3
HR, CI and p-values from the Cox model that included stage and PID1 expression.
4
Missing data for these variables were included in the models as a “missing” category.