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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Pediatr Res. 2013 Sep 4;74(6):721–729. doi: 10.1038/pr.2013.162

Table 5.

Population Pharmacokinetic Random Effects Variances and Correlations

Volume (uV) Clearance (uCl) Endogenous
Infusion Rate (uR)
Volume (uV) 0.08506 - -
Clearance (uCl) 0.0a 0.22636 -
Endogenous Infusion Rate (uR) 0.0 a 0.87606 0.14492

Random effect variances on the diagonal and correlations between the random effects are displayed on the off diagonal.

a

Correlation set to 0.0 (zero) based upon review of plots of uVi vs. uCli, and uVi vs. uRi.