Table 1.

Metabolite concentrations in plasma of normal and Snell dwarf mice.^a

Plasma	Normal	Dwarf	p
Taurine	367 ± 27	727 ± 35	< 0.0001
Hypotaurine	4.9 ± 0.5	8.1 ± 0.7	< 0.002
Methionine	96 ± 5	153 ± 15	< 0.001
Cystine	62 ± 3	33 ± 3	< 0.0001
Cysteine	19 ± 1	16 ± 2	> 0.2
Eh(Cystine/Cysteine)	−88 ± 2	−92 ± 2	>0.1
GSH	10 ± 2	5 ± 1	< 0.02#
GSSG	7 ± 2	6 ± 1	>0.6
Eh(GSSG/GSH)	−114 ± 4	−98 ± 3	< 0.002
Glutamate	61 ± 7	39 ± 2	< 0.006
Glutamine	606 ± 22	493 ± 33	< 0.009
Aspartate	19 ± 1	20 ± 2	> 0.4

^aData represent the mean ± SEM (standard error of the mean) from 16 normal and 16 dwarf mice, with equal numbers of males and females in each group. P-values correspond to the effect of the Snell dwarf genotype in a two factor ANOVA adjusting for differences between males and females. Concentrations are expressed in units of μmoles/liter for plasma metabolites and in mV for redox potentials.

^#Indicates an effect that is seen in one sex only (see Table 4).