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. Author manuscript; available in PMC: 2014 Dec 5.
Published in final edited form as: Cell Stem Cell. 2013 Dec 5;13(6):676–690. doi: 10.1016/j.stem.2013.10.008

Figure 7. THO controls pluripotency gene mRNA export to regulate ESC self-renewal and differentiation.

Figure 7

In ESCs, THO is necessary for the efficient export of pluripotency gene mRNAs and the maintenance of self-renewal. Upon differentiation or Thoc5 down-regulation, decreased Thoc5 level results in impaired pluripotency gene mRNA export and expression, leading to differentiation. By post-transcriptionally regulating pluripotency gene expression, THO provides an important layer of control to regulate ESC self-renewal and differentiation.