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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Nat Commun. 2014;5:3315. doi: 10.1038/ncomms4315

Figure 6. A scheme of the crosstalk between Hippo signaling and FoxO1.

Figure 6

In cardiomyocytes, YAP and FoxO1 form a functional complex that mediates catalase and MnSOD expression. In response to I/R, activation of the Hippo signaling cascade induces YAP inactivation, which leads to antioxidant gene suppression, ROS accumulation, and cell death.