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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Mol Immunol. 2013 Nov 1;57(2):247–254. doi: 10.1016/j.molimm.2013.09.005

Figure 4.

Figure 4

HP-mediated adherence of BoNT/A to Tg-hCR1 RBCs in vivo. Groups of three Tg-hCR1 mice received intravenous biotinylated recombinant inactive BoNT/A and either the 6A-HP + 4LCA-HP combination (Panel A) or rabbit BoNT anti-serum (Panel B). RBCs were collected at 5, 30, 90 minutes, and 2 and 24 hours following the injection and stained with PE-streptavidin (PE-SA). Histograms show the RBC PE signal over time. Panel C plots the histogram data as geometric mean fluorescence intensity (GMF) (HP RBCs, circles; anti-serum RBCs, squares).