Table 3.
Final Hierarchical Linear Model for PCS and MCS
| PCS | MCS | |||||
|---|---|---|---|---|---|---|
| Unconditional | Conditional | Unconditional | Conditional | |||
| Factor | Model Coefficient (SE) |
Model 1 Coefficient (SE) |
Final Model Coefficient (SE) |
Model Coefficient (SE) |
Model 1 Coefficient (SE) |
Final Model Coefficient (SE) |
| Fixed effects | ||||||
| Intercept | 48.41 (0.78)*** | 60.12 (4.35)*** | 59.60 (3.57)*** | 49.83 (0.97)*** | 48.76 (4.56)*** | 45.98 (3.54)*** |
| Time (linear rate of change) | −0.12 (0.15) | −0.88 (0.42)* | −0.78 (0.36)* | −0.13 (0.17) | 0.38 (0.29) | 0.29 (0.22) |
| Intercept | ||||||
| Demographic and Clinical Covariates | ||||||
| Age | −0.19 (0.05)*** | −0.14 (0.04)** | 0.05 (0.06) | 0.11 (0.04)* | ||
| Gender (ref. male) | −3.96 (1.52)** | −2.27 (1.26) | −2.04 (1.36) | −0.29 (1.07) | ||
| Marital Status (ref. no) | 0.48 (1.38) | −0.64 (1.12) | 4.80 (1.45)** | 3.56 (1.13)** | ||
| Ethnicity (ref. Hispanic) | −4.07 (1.39)** | −4.06 (1.12)*** | 2.12 (1.47) | 2.28 (1.15)* | ||
| Transplant Risk Status (ref. low) | ||||||
| High/Very High | −0.38 (1.56) | 0.63 (1.28) | −3.39 (1.69)* | −2.55 (1.31) | ||
| Intermediate | 2.09 (1.59) | 2.42 (1.28) | −1.47 (1.68) | −0.69 (1.30) | ||
| HCT-CI (ref. 0) | ||||||
| >=3 Score | −2.59 (1.49) | −2.00 (1.21) | 2.44 (2.15) | 2.81 (1.60) | ||
| 1 or 2 Score | −1.40 (1.56) | −1.30 (1.26) | 6.28 (2.30)** | 4.87 (1.73)** | ||
| Conditioning Type (ref. RIC) | 0.60 (1.41) | 0.38 (1.16) | −2.78 (1.51) | −2.47 (1.19)* | ||
| Time Varying Predictors | ||||||
| Evidence of Disease1 (ref. none) | −1.45 (0.85) | |||||
| Immune Suppression (ref. none) | −2.85 (0.79)*** | |||||
| Physical Symptom Distress | −0.47 (0.06)*** | −0.62 (0.05)*** | ||||
| Linear (interaction) | ||||||
| Gender by Time | 0.59 (0.29)* | 0.47 (0.25) | ||||
| Physical Symptom Distress by Time | 0.03 (0.01)* | |||||
| Variance components | ||||||
| Within-person | 20.87 (1.76)*** | 21.27 (1.79)*** | 20.50 (1.50)*** | 33.98 (2.76)*** | 33.54 (2.69)*** | 30.11 (2.20)*** |
| In intercept | 62.80 (10.99)*** | 49.79 (9.69)*** | 27.16 (6.10)*** | 95.50 (17.13)*** | 75.07 (15.02)*** | 31.10 (7.53)*** |
| In linear rate | 0.69 (0.39)* | 0.37 (0.33) | 0 | 1.11 (0.54)* | 0.83 (0.44)* | 0 |
| Covariance | −0.22 (1.72) | −0.22 (1.55) | 0.88 (0.76) | −6.20 (2.87)* | −4.84 (2.51) | −0.03 (0.81) |
| Goodness-of-fit deviance | 3652.2 | 3587.9 | 3472.7 | 3850.9 | 3783.3 | 3638.1 |
| Model comparison (χ2 [df]) | 64.3 (10) | 179.5 (14)*** | 67.6 (11) | 212.8 (12)*** | ||
| R2 at intercept | 20.7% | 56.8% | 21.4% | 67.4% | ||
| R2 at linear rate | 46.4% | 100% | 25.2% | 100% | ||
Abbreviations: PCS, Physical Component Score; MCS, Mental Component Score; SD, standard deviation; HSCT, hematopoietic stem-cell transplantation; RIC, reduced-intensity conditioning; HCT-CI, hematopoietic stem-cell transplantation – comorbidity index.
NOTE:
1
Of those classified as having evidence of disease, 5 (14.7%) had achieved a CR but were continuing a course of disease specific treatment.
*
p<.05;
**
p<.01;
***
p<.001.
Physical Symptom Distress was centered on the 3 year mean of 34.04 and age was centered on the 3 year mean of 43.95. Intercept here means 3 years post HSCT. Education was not significant in the unconditional model.