Table 4.
Final Hierarchical Linear Model for FACT-G
| FACT-G |
|||
|---|---|---|---|
| Unconditional | Conditional | ||
| Factor | Model Coefficient (SE) |
Model 1 Model 1 |
Final Model Coefficient (SE) |
| Fixed effects | |||
| Intercept | 87.65 (1.39)*** | 95.61 (7.80)*** | 89.87 (5.48)*** |
| Time (linear rate of change) | −0.39 (0.25) | −1.00 (0.41)* | −0.20 (0.31) |
| Intercept | |||
| Demographic and Clinical Covariates | |||
| Age | −0.13 (0.10) | −0.02 (0.07) | |
| Gender (ref. male) | −3.01 (2.36) | 0.09 (1.65) | |
| Marital Status (ref. no) | 2.19 (3.00) | 2.38 (2.21) | |
| Ethnicity (ref. Hispanic) | −0.92 (2.53) | −0.89 (1.75) | |
| Transplant Risk Status (ref. low) | |||
| High/Very High | −4.71 (2.88) | −2.43 (2.03) | |
| Intermediate | −1.53 (2.91) | −0.57 (2.02) | |
| HCT-CI (ref. 0) | |||
| >=3 Score | 0.19 (2.74) | 0.86 (1.91) | |
| 1 or 2 Score | 3.47 (2.85) | 3.75 (1.98) | |
| Conditioning Type (ref. RIC) | −2.25 (2.57) | −2.27 (1.81) | |
| Time Varying Predictors | |||
| Evidence of Disease1 (ref. none) | −1.09 (1.22) | ||
| Immune Suppression (ref. none) | −1.23 (1.18) | ||
| Physical Symptom Distress | −1.03 (0.06)*** | ||
| Variance components | |||
| Within-person | 48.99 (4.07)*** | 48.63 (4.03)*** | 37.05(3.12)*** |
| In intercept | 221.56 (35.44)*** | 203.99 (34.59)*** | 100.03 (19.08)*** |
| In linear rate | 2.44 (1.05)** | 2.17 (1.04)* | 0.55 (0.61) |
| Covariance | −9.29 (5.66) | −7.84 (5.68) | −3.43 (3.13) |
| Goodness-of-fit deviance | 4180.3 | 4141.4 | 3881.4 |
| Model comparison (χ2 [df]) | 38.9 (10) | 298.9 (13)*** | |
| R2 at intercept | 7.9% | 54.9% | |
| R2 at linear rate | 11.1% | 77.5% | |
Abbreviations: FACT-G, Functional Assessment for Cancer Therapy-General; SD, standard deviation; RIC, reduced-intensity conditioning; HCT-CI, hematopoietic stem-cell transplantation – comorbidity index; SE, standard error; HSCT, hematopoietic stem-cell transplantation.
NOTE:
1
Of those classified as having evidence of disease, 5 (14.7%) had achieved a CR but were continuing a course of disease specific treatment.
*
p<.05;
**
p<.01;
***
p<.001.
Physical Symptom Distress was centered on the intercept mean of 34.04 and age was centered on the intercept mean of 43.95. Intercept here means 3 years post HSCT. Education was not significant in the unconditional model.