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. Author manuscript; available in PMC: 2014 Mar 24.
Published in final edited form as: J Neurovirol. 2013 Aug 27;19(5):471–478. doi: 10.1007/s13365-013-0200-z

Figure 1. Proposed model of relationship between YWHAE (14-3-3ε) and HIV accessory protein gp120.

Figure 1

A. Binding of YWHAE (14-3-3ε) is necessary to prevent apoptosis in neurons via is association with phosphorylated B-cell lymphoma 2 (Bcl-2) antagonist of cell death (BAD) protein bound to Bcl-2, thereby suppressing apoptosis. B. Gp120-dependent dephosphorylation of BAD at Serine-112 prevents YWHAE binding allowing for its association with the Bcl-XL leading to apoptosis. Apoptosis of the neuron leads to the release of YWHAE and its eventual degradation.