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α-CTx LvIA selectively blocks rat α3β2 nAChRs. nAChR subtypes were expressed as described in Materials and Methods; C indicates control responses to ACh. Oocytes were then exposed to 100 nM or 10 μM peptide for 5 min, followed by application of ACh (arrows) and washing to allow recovery of blockade (if produced by α-CTx LvIA). Typical traces are shown. The peptide almost completely blocked α3β2 (A) but not α2β2 (B), α6/3β2β3 (C), or mouse α1βδε (D) nAChR subtypes.
