Table 2.

Protective efficacy of EpiP vaccination in the peritonitis model

Treatment	Survived/total animals	%	PE	P
Alum	2/32	6	–	–
EpiP	11/32	34	30	0.0054
EpiP-S393A	10/31	32	28	0.0093

A lethal dose of S. aureus Newman strain was used to challenge CD1 mice (n=32/group, 2 separate experiments), and survival rates were followed for 1 wk. Mice were vaccinated intraperitoneally and challenged with the S. aureus strain Newman. Statistical analysis was performed by 1-tailed Fisher's exact test; comparisons are vs. alum treatment. Protective efficacy (PE) = 1 − (D_V/D_C), where D_V is dead vaccinated (%), and D_C is dead control (%).