Figure 4.

Markers of oxidative damage in skeletal muscle and brain of SynTgSod1^−/− mice. A) Lipid peroxidation assessed by F2-isoprostane content of skeletal muscle and brain of WT, Sod1^−/−, and SynTgSod1^−/− mice. B) Western blot analysis of changes in 3-NT content of skeletal muscles of Sod1^−/−, WT, and SynTgSod1^−/− mice and densitometric quantification of the blots. C) Representative Western blots of the content of PRXV, a peroxynitrite reductase, in skeletal muscle of Sod1^−/−, WT, and SynTgSod1^−/− mice and densitometric quantification of the blots. *P < 0.05 vs. WT.