Table 2.
Comparisons of serum LYVE-1 levels.
| Variables | Categories | No. | LYVE-1 (pg/mL) | P value |
|---|---|---|---|---|
| Gender | male | 50 | 1,405 ± 310 | 0.372 |
| female | 8 | 1,510 ± 265 | ||
| Histological type | NSCLC | 40 | 1,466 ± 314 | 0.172 |
| SCLC | 14 | 1,340 ± 214 | ||
| Stage | I | 11 | 1,742 ± 211 | 0.0001 |
| II | 9 | 1,398 ± 267 | ||
| III | 11 | 1,426 ± 383 | ||
| IV | 26 | 1,272 ± 190 | ||
| Smoking history | never | 7 | 1,622 ± 219 | 0.167 |
| ex | 24 | 1,398 ± 355 | ||
| current | 26 | 1,381 ± 263 | ||
| Symptoms | absent | 26 | 1,515 ± 325 | 0.029 |
| present | 32 | 1,342 ± 266 | ||
| N stage | 0 | 23 | 1,547 ± 308 | 0.009 |
| ≥1 | 35 | 1,336 ± 274 | ||
| M stage | 0 | 31 | 1,530 ± 329 | 0.0009 |
| 1 | 26 | 1,272 ± 190 |
Serum LYVE-1 levels were compared in each group according to gender, histological type, stage, smoking history, presence of symptoms, lymph node metastasis, and distant metastasis. Data are presented as n, mean ± SD. Differences in gender, histological type, symptoms, lymph-node metastasis, and distant metastasis were evaluated by Student's t-test, except for stage and smoking history, where analysis of variance was used.
Abbreviations: LYVE-1, lymphatic vessel endothelial hyaluronan receptor-1; NSCLC, non-small-cell lung cancer; SCLC, small-cell lung cancer; N, lymph-node metastasis; M, distant metastasis.