Table 1.
Multivariate analysis for cardiovascular events with different degrees of adjustments (Cox regression analysis)
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | |
|---|---|---|---|---|---|
| Moderate fat content | 1.51 (0.99 to 2.29) | 1.44 (0.93 to 2.23) | 1.31 (0.84 to 2.05) | 1.30 (0.84 to 2.01) | 1.49 (0.99 to 2.26) |
| Severe fat content | 1.92 (1.32 to 2.80)** | 1.74 (1.16 to 2.63)** | 1.49 (0.97 to 2.30) | 1.43 (0.93 to 2.18) | 1.76 (1.21 to 2.56)** |
| Study group | 1.34 (0.98 to 1.85) | 1.29 (0.92 to 1.80) | 1.28 (0.92 to 1.78) | ||
| Age | 1.06 (1.03 to 1.09)*** | 1.05 (1.02 to 1.08)** | 1.05 (1.02 to 1.08)** | 1.05 (1.02 to 1.07)** | 1.05 (1.02 to 1.08)** |
| Gender | 2.39 (1.71 to 3.34)* | 1.91 (1.34 to 2.71)*** | 1.80 (1.26 to 2.57)** | 1.83 (1.29 to 2.60)** | 1.92 (1.36 to 2.72)*** |
| LDL-cholesterol | 1.17 (0.99 to 1.39) | 1.15 (0.97 to 1.37) | |||
| Smoking (pack-years) | 1.02 (1.01 to 1.03)*** | 1.02 (1.01 to 1.03)*** | 1.02 (1.01 to 1.03)*** | 1.02 (1.01 to 1.03)*** | |
| Alcohol consumption (group 1) | 0.93 (0.59 to 1.45) | 0.92 (0.59 to 1.44) | |||
| Alcohol consumption (group 2) | 0.84 (0.44 to 1.60) | 0.81 (0.42 to 1.54) | |||
| Systolic blood pressure | 1.01 (1.00 to 1.02)** | 1.01 (1.00 to 1.02)* | 1.01 (1.00 to 1.02)** | 1.01 (1.00 to 1.02)** | |
| Body mass index | 0.99 (0.96 to 1.03) | 0.97 (0.93 to 1.01) | |||
| QUICKI | 0.12 (0.02 to 0.90)* | 0.16 (0.03 to 0.99)* |
CVD event occurred in 13.5% of the participants with no fat in the liver (97/720), 24.2% (30/124) of participants having moderate liver fat content and 29.2% (42/144) of the participants having severe fatty liver. HRs with 95% CI with different degrees of adjustments are presented. Alcohol consumption was divided into groups (reference group: less than 1 g/week in men and women, group 1: less than 210 g/week in men and less than 140 g/week in women, group 2: more than 210 g/week in men and more than 140 g/week in women). Model 1: adjustment for study group, age and gender. Model 2: further adjustments for LDL-cholesterol, smoking, alcohol consumption, systolic blood pressure and body mass index. Model 3: further adjustment for QUICKI. Model 4: adjustments with statistically significant covariates. Model 5: adjustments with statistically significant covariates without QUICKI. *p<0.05,**p<0.01,***p<0.001.
CVD, cardiovascular disease; LDL, low-density lipoprotein; QUICKI, quantitative insulin sensitivity check index.