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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Clin Immunol. 2014 Jan 15;151(1):29–42. doi: 10.1016/j.clim.2014.01.002

Figure 2. SLE sera biomarkers of disease were decreased in NZB/W mice following HDACi treatment.

Figure 2

Figure 2

Figure 2

(A) Measurement of sera anti-dsDNA in NZW and NZB/W mice at 22 weeks-of-age (prior to treatment) and at 38 weeks-of-age (following 16 weeks of treatment). Treatment with ITF2357 (10 mg/kg) significantly decreased anti-dsDNA production in 38-week-old NZB/W mice. (B-C) Sera IgG2a and total IgG levels were decreased in NZB/W mice treated with the HDACi (n ≥ 5; **p < 0.005).