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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Clin Immunol. 2014 Jan 15;151(1):29–42. doi: 10.1016/j.clim.2014.01.002

Figure 4. Glomerular mRNA levels were assessed in NZB/W mice.

Figure 4

Figure 4

Figure 4

(A) One kidney was removed from each NZW and NZB/W mouse and pooled by group. A glomerular isolation was performed and mRNA levels were quantified using RT-PCR. IL-10 was decreased in the glomeruli of NZB/W mice injected with ITF2357 (10 mg/kg) compared to those receiving the vehicle control or ITF2357 (5 mg/kg). (B) mRNA levels of TGF-β were increased in NZB/W mice treated with ITF2357 (5mg/kg), but there was no significant difference in NZB/W mice treated with ITF2357 (10mg/kg) when compared to DMSO treated NZB/W mice. (C) Treatment with ITF2357 significantly decreased glomerular IL-6 in a dose-dependent manner (n ≥ 5; **p < 0.005, ***p < 0.0005, ****p < 0.0005).