Figure 9. ITF2357 increases histone H3 acetylation in the kidney.
(A) Five μM kidney sections from 38-week-old NZW and NZB/W mice treated with DMSO or ITF2357 (5mg/kg or 10mg/kg) were stained for acetyl-histone H3 (lys9). Treatment with ITF2357 (10mg/kg) increased the percentage of FITC (green) stained acetylated H3 histones colocalized with nuclear DAPI (blue) stain in both NZW and NZB/W mice (n ≥ 5).