Table 2.
Basic vascular parameters, constrictions, and relaxations of the femoral artery in young female Wistar-Kyoto (WKY), borderline hypertensive (BHR), and spontaneously hypertensive (SHR) rats exposed to crowding.
| WKY | BHR | SHR | ||||
|---|---|---|---|---|---|---|
| Control | Stress | Control | Stress | Control | Stress | |
| ND (µm) | 579 ± 12 | 574 ± 15 | 630 ± 14 | 595 ± 10 | 537 ± 23+ | 538 ± 11+ |
| Basal tension (kPa) | 2.04 ± 0.21 | 1.92 ± 0.26 | 2.82 ± 0.20 | 2.24 ± 0.24 | 2.77 ± 0.53 | 2.84 ± 0.32 |
| NE—phasic (kPa) | 1.34 ± 0.27 | 2.42 ± 0.47 | 4.72 ± 0.64x | 3.75 ± 0.53 | 5.01 ± 1.05x | 5.75 ± 0.73x+ |
| NE—tonic (kPa) | 0.15 ± 0.04 | 0.35 ± 0.15 | 6.36 ± 1.78x | 2.36 ± 0.63x∗ | 7.42 ± 2.02x | 7.14 ± 1.74x+ |
| Ser (kPa) | 19.0 ± 0.6 | 19.9 ± 1.1 | 22.0 ± 1.5 | 23.7 ± 1.7 | 23.4 ± 1.7 | 21.9 ± 1.1 |
| Ser—after L-NAME (kPa) | 24.7 ± 0.5† | 24.3 ± 1.7† | 25.0 ± 1.8 | 28.9 ± 1.8† | 27.7 ± 2.1 | 27.4 ± 1.3† |
| KPSS (kPa) | 25.1 ± 1.2 | 25.0 ± 2.2 | 26.6 ± 2.7 | 32.6 ± 2.6x | 34.2 ± 2.8x+ | 29.2 ± 2.2 |
| SNP E max (%) | 99 ± 1.1 | 96 ± 1.3 | 98 ± 1.5 | 97 ± 2.0 | 98.0 ± 2.0 | 95 ± 2.3 |
| SNP pD2 (−log(mol/L)) | 7.96 ± 0.05 | 8.07 ± 0.06 | 8.09 ± 0.09 | 7.99 ± 0.11 | 7.69 ± 0.07x+ | 7.63 ± 0.07x+ |
| ACh E max (%) | 88 ± 1.9 | 91 ± 1.8 | 81 ± 1.9 | 85 ± 2.1 | 58 ± 1.9x+ | 60 ± 1.9x+ |
| ACh pD2 (−log(mol/L)) | 7.39 ± 0.04 | 7.30 ± 0.03 | 7.50 ± 0.04 | 7.49 ± 0.05x | 7.36 ± 0.05 | 7.53 ± 0.05x |
Values represent mean ± SEM of 7–12 rats. ND: normalized diameter of the femoral artery at 13.3 kPa; NE: norepinephrine (10 µmol/L); Ser: serotonin (1 μmol/L); L-NAME: NG-nitro-L-arginine methyl ester; KPSS: PSS in which NaCl was exchanged for an equimolar concentration of KCl; SNP: sodium nitroprusside; ACh: acetylcholine; x P < 0.05 versus WKY respective group (control/stress); + P < 0.05 versus BHR respective group (control/stress); *P < 0.05 versus control group of the same genotype; † P < 0.05 versus the same group before L-NAME.