Risk-2	Pathology of BRCA1-associated carcinoma of the breast
	a. BRCA1-associated carcinomas of the breast frequently exhibit a characteristic histopathological and immunohistochemical phenotype: invasive carcinoma (NOS) with a growth pattern similar to that of medullary carcinoma G3 morphology negativity for estrogen receptors, progesterone receptors and HER2/neu (triple negative)
Level of evidence 2a	(Honrado E et al. 2006; Lakhani SR et al. 1998; Lakhani SR et al. 2005)
	b. In cases where these characteristics are present, the pathologist should draw attention to the possibility of an inherited susceptibility.
GCP	(Honrado E et al. 2006; Lakhani SR et al. 1998; Lakhani SR et al. 2005)