Stag-6	Open excisional biopsy
	a. Primary, open diagnostic excision biopsy should only be performed in exceptional cases, as when an imaging-guided intervention is not possible or too risky.
GCP	(Albert US et al. 2008; Gruber R et al. 2008)
Grade of recommendation A	b. In the case of non-palpable changes, it is always important to perform preoperative marking. Adequate resection via imaging methods must also be demonstrated.
Level of evidence 3b	(Albert US et al. 2008)
Grade of recommendation A	c. During the preoperative wire marking of non-palpable lesions, the wire should penetrate the focal lesion and project beyond the lesion by less than 1 cm. In cases where the wire does not penetrate the focal lesion, the distance between the wire and the margin of the lesion should be ≤ 1 cm. In non-space-occupying processes, marking of the surgically relevant target volume may be useful.
Level of evidence 3b	(Albert US et al. 2008)
	d. The material collected during the operation should be clearly marked and sent to the pathologists without any incision of the tissue material obtained.
GCP	(Albert US et al. 2008)
	e. An intraoperative decision as to whether a lesion is benign or malignant on the basis of a frozen section should be made only in exceptional cases. Prerequisites for a frozen section of surgical specimens are: The lesion is palpable intraoperatively and in the specimen The lesion is sufficiently large (generally > 10 mm)
GCP	(Albert US et al. 2008)