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a. Determination of the histological node status (pN
status) is part of the surgical treatment of invasive
breast cancer. This should be done by means of sentinel
lymph node biopsy (SLNB). |
GCP
|
(Kuehn T et al. 2005; Lyman GH et al. 2005; NICE 2009;
NZGG 2009) |
|
b. SLNB is equivalent to axillary dissection in terms of
local control in SLN-negative patients. |
Level of evidence
1b
|
(Krag DN et al. 2010; NZGG 2009) |
|
c. Morbidity after SLNB is significantly reduced compared
with axillary dissection. |
Level of evidence
1a
|
(Fleissig A et al. 2006; Mansel RE et al. 2006; NICE
2009; Veronesi U et al. 2003) |
|
d. Axillary dissection must be performed in patients in
whom no SLN is detected. |
GCP
|
|
Grade of recommendation
A
|
e. In patients who exhibit a positive SLN
(macrometastasis), axillary dissection with removal of
at least 10 lymph nodes from levels I and II is
indicated. |
Level of evidence
1b
|
(NZGG 2009) |
|
f. For patients with pT1-pT2/cN0 tumors undergoing
breast-conserving surgery followed by tangential field
irradiation and who exhibit one or two positive sentinel
lymph nodes, there is the option of refraining from
axillary dissection. |
GCP
|
(Giuliano AE et al. 2010) |
|
g. This procedure requires extensive preliminary
information and briefing of the patient.The
process and outcome quality must be evaluated
prospectively in conjunction with quality assuring
measures. |
GCP
|
|
|
h. Axillary dissection is not necessary if only
micrometastases are present. |
GCP
|
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