RT-4	Radiotherapy of the chest wall after mastectomy
	a. Postoperative radiotherapy of the chest wall after mastectomy reduces the risk of locoregional recurrence.
Level of evidence 1a	(Clarke M et al. 2005; EBMG 2006; NCCN 2011; NHMRC2001; NICE 2009; NZGG 2009; Peto R 2006; Shafiq J et al. 2007; SIGN 2005; Whelan T et al. 2007)
	b. In patients with a high risk of a local recurrence, overall survival is also improved.
Level of evidence 1a	(Clarke M et al. 2005; Darby S et al. 2009; Fernando SA et al. 2007; Gebski V et al. 2006; Harris EE 2008; Jagsi R et al. 2009; Kyndi M et al. 2008b; Kyndi M et al. 2008a; NCCN 2011; NICE 2009; Nielsen HM et al. 2006a; Nielsen HM et al. 2006b; NZGG 2009; Overgaard M et al. 2007; Peto R 2006; Poortmans P 2007; Rowell NP 2009; Rowell NP 2010; Voordeckers M et al. 2009; Whelan T et al. 2007)
	c. Postoperative radiotherapy of the chest wall after mastectomy is therefore indicated in the following situations:
Grade of recommendation A	T3/T4
Level of evidence 1a	(NCCN 2011; NICE 2009; NZGG 2009)
Grade of recommendation B	pT3 pN0 R0 only in the presence of other risk factors (lymphatic vessel invasion, G3 grade, close resection margin, premenopausal status, age < 50 years)
Level of evidence 2b	(Floyd SR et al. 2009; Kunkler I 2010; McCammon R et al. 2008; Rowell NP 2009; Russell NS et al. 2009)
Grade of recommendation A	R1-/R2 resection and no possibility of a complete repeat resection
Level of evidence 1a	(NCCN 2011; NICE 2009; NZGG 2009)
Grade of recommendation A	pN+ (> 3 lymph nodes)
Level of evidence 1a	(NCCN 2011; NICE 2009; NZGG 2009)
Grade of recommendation A	d. After primary (neoadjuvant) systemic therapy, the indication for radiotherapy should be based on the pretherapeutic T and N category, regardless of the degree of response to the primary systemic therapy.
Level of evidence 2a	(Buchholz TA et al. 2002; Buchholz TA et al. 2008; Buchholz TA 2009; Garg AK et al. 2007; Goldhirsch A et al. 2009; Huang EH et al. 2006; Kaufmann M et al. 2003; Kaufmann M et al. 2010; NCCN 2007; NCCN 2011)