Met-5	Contraindications to endocrine therapy
Grade of recommendation A	Endocrine therapy is not indicated in the following cases: need to achieve rapid remission to prevent severe symptoms in the affected organ negative hormone receptor status brain metastases (no adequate/sufficient therapy).
Level of evidence 1b	(Fossati R et al. 1998; NICE 2009; Stockler M et al. 1997; Stockler M et al. 2000)