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. 2013 Dec 13;35(2):159–194. doi: 10.1210/er.2013-1087

Figure 11.

Figure 11.

Darkfield illumination photomicrographs of proTRH mRNA in the hypothalamic PVN in (A) fed, (B) fasted, and (C) fasted animals receiving leptin. Note the marked reduction in silver grains over neurons in the PVN in the fasted animals but restoration to normal in the fasted animals receiving leptin. III, Third ventricle. [Reproduced from C. Fekete and R. M. Lechan: Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase. Front Neuroendocrinol. 2007;28:97–114 (58), with permission. © Elsevier.]