Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Dec 13;35(2):159–194. doi: 10.1210/er.2013-1087

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 by The Endocrine Society

PMC Copyright notice

Figure 8. — In situ hybridization autoradiograms showing the effect of hypo- and hyperthyroidism on proTRH mRNA level in the medial parvocellular subdivision of the PVN. A substantial increase in silver grain accumulation is observed in the hypothyroid animal (A) compared to the fed control (B). In contrast, hyperthyroidism results in a marked reduction of proTRH mRNA level in the PVN (C). [Modified from E. M. Dyess et al: Triiodothyronine exerts direct cell-specific regulation of thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus. Endocrinology. 1988;123:2291–2297 (115), with permission. © The Endocrine Society. And from C. Fekete and R. M. Lechan: Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase. Front Neuroendocrinol. 2007;28:97–114 (58), with permission. © Elsevier.]