Table 3.
PDE Genes
| Gene | No. of Transcripts | Isoforms (Protein Coding) | Size Range, aa | Chromosome Locationa |
|---|---|---|---|---|
| PDE1A | 13 | 4 | 535–545 | 2q32.1 chr2:183,004,763-183,387,919 |
| PDE1B | 8 | 2 | 516–536 | 12q13.2 chr12:54,943,134-54,973,023 |
| PDE1C | 11 | 5 | 634–769 | 17p14.3 chr7:31,790,793-32,338,941 |
| PDE2A | 27 | 4 | 932–941 | 11q13.4 chr11:72,287,185-72,385,635 |
| PDE3A | 3 | 1 | 1141 | 12p12.2 chr12:20,522,179-20,837,315 |
| PDE3B | 5 | 1 | 1112 | 11p15.2 chr11:14,665,269-14,892,350 |
| PDE4A | 10 | 4 | 647–886 | 19p13.2 chr19:10,527,449-10,580,305 |
| PDE4B | 19 | 5 | 564–736 | 1p31.3 chr1:66,258,197-66,840,259 |
| PDE4C | 16 | 5 | 606–712 | 19p13.11 chr19:18,318,771-18,366,229 |
| PDE4D | 27 | 9 | 507–809 | 5q11.2-q12.1 chr5:58,264,865-59,817,947 |
| PDE5A | 12 | 2 | 833–875 | 4q26 chr4:120,415,550-120,550,146 |
| PDE6A | 3 | 1 | 860 | 5q32 chr5:149,237,519-149,324,356 |
| PDE6B | 12 | 3 | 575–854 | 4p16.3 chr4:619,373-664,571 |
| PDE6C | 2 | 1 | 858 | 10q23.33 chr10:95,372,345-95,425,767 |
| PDE7A | 8 | 2 | 456–482 | 8q13.1 chr8:66,629,745-66,754,557 |
| PDE7B | 2 | 1 | 450 | 6q23.3 chr6:136,172,834-136,516,712 |
| PDE8A | 16 | 3 | 783–829 | 15q25.3 chr15:85,523,671-85,682,376 |
| PDE8B | 9 | 5 | 788–885 | 5q13.3 chr5:76,506,274-76,725,632 |
| PDE9A | 29 | 13 | 433–593 | 21q22.3 chr21:44,073,746-44,195,619 |
| PDE10A | 3 | 1 | 789 | 6q27 chr6:165,740,776-166,075,588 |
| PDE11A | 14 | 5 | 489–933 | 2q31.2 chr2:178,492,797-178,973,066 |
This gene annotation was provided by the Ensembl data. The Ensembl includes both automatic annotation and manual curation. All Ensembl transcripts are based on experimental evidence, and thus the automated pipeline relies on the mRNAs and protein sequences deposited into public databases from the scientific community. The manual curation occurs through the merging of the automated method with the Consensus Coding Sequence (CCDS) in a unique transcript. However, the number of coding transcripts used to assemble this table only refers to the information acquired through the manual curation because it provides a better confidence in the actual number of known isoforms. Furthermore, this information may also explain some missing known isoforms that were not called by the automated method and are known by the scientific community.
Based on GRCh37/h19.