Table 9.
Surveillance During Mitotane Therapy
| Regular Laboratory Surveillance for Mitotane |
| Mitotane level (monthly until therapeutic, then every 3 mo) |
| Every 3 mo |
| Complete blood count |
| Liver function tests (AST, ALT) |
| Cholestatic parameters (ALP, GGT, bilirubin) |
| Free T4, TSH |
| Cholesterol |
| Renin |
| ACTH, cortisol, 24-h urine free cortisola |
| Males: bioavailable testosterone, LH, FSH |
a
Use of these parameters is limited by the effects of mitotane on cortisol levels and cortisol metabolism and need to be interpreted with caution.