Table 1.
Baseline characteristics of children with CD and AICS1.
| CD (n=93) | AICS (n=31) | P-value | |
|---|---|---|---|
| Chronologic age at time of pre-surgery bone age | 12.3 ± 2.9 | 10.3 ± 4.5 | 0.0223* |
| Females(%)/males(%) | 43(46.2)/50(53.8) | 22(71.0)/9(29.0) | 0.0221* |
| 0.7981 | |||
| Race (%) | 4 (4.3) | 2 (6.5) | |
| Asian | 6 (6.4) | 3 (9.7) | |
| Black | 61 (65.6) | 21 (67.7) | |
| White Other/unknown |
22 (23.7) | 5 (16.1) | |
| 0.3301 | |||
| Ethnicity (%) | |||
| Latino or Hispanic | 24 (25.8) | 5 (16.1) | |
| 66 (71.0) | 26 (83.9) | ||
| Not Latino or Hispanic Unknown | 3 (3.2) | 0 | |
| Duration of symptoms until surgery (months) | 32.5 ± 21.0 | 26.2 ± 25.1 | 0.0178* |
| BMI Z-score | 2.3 ± 0.6 | 2.1 ± 0.7 | 0.0742 |
| Height SDS | −1.1 ±1.2 | −1.1 ± 1.6 | 0.9872 |
| Breast tanner stage (females) | 3.0 (3.0, 5.0) | 2.5 (1.0, 4.5) | 0.0741 |
| Testicular volume by Prader orchidometer, cc (males) | 8.0 (5.4, 10.0) | 4.5 (2.5, 15.0) | 0.1663 |
| Bone age, yr | 12.8 ± 2.9 | 10.7 ± 4.6 | 0.0312* |
| Bone age - Chronological age (difference in yr) | 0.5 ± 1.3 | 0.4 ± 1.4 | 0.4861 |
| Bone age Z-score | 0.6 ± 1.4 | 0.5 ± 1.8 | 0.8865 |
| ACTH, pg/mL | 53 ± 44 | 6 ± 3 | <0.0001* |
| IGF-1 Z-score | −0.4 ± 1.6 | 0.1 ± 1.8 | 0.1495 |
| DHEA, ng/dL | 595 ± 502 | 156±253 | <0.0001* |
| Normalized ratio of mean for age and gender DHEA, | 2.2 ± 2.0 | 1.0 ± 1.0 | <0.0001* |
| DHEA-S, μg/ dL | 236 ± 203 | 63 ± 83 | <0.0001* |
| Normalized ratio of mean for age and gender DHEA-S | 2.2 ± 2.0 | 0.9 ± 0.8 | <0.0001* |
| Androstenedione, ng/dL | 142±118 | 146±101 | 0.7952 |
| Normalized ratio of mean for age and gender Androstenedione, | 2.6 ± 2.3 | 4.4 ± 8.2 | 0.2031 |
| Estradiol, pg/mL | 23 ± 31 | 31 ± 44 | 0.2376 |
| Normalized ratio of mean for age and gender estradiol | 1.4±1.2 | 1.7±1.4 | 0.31 |
| Testosterone, ng/dL | 74 ± 137 | 40 ± 70 | 0.0471* |
| Normalized ratio of mean for age and gender Testosterone | 1.2± 1.2 | 1.4 ± 1.2 | 0.1869 |
| UFC, μg/24 hr | 322 ± 353 | 286 ± 259 | 0.2548 |
| Midnight cortisol, μg/dL | 19.7 ± 15.0 | 20.5 ± 13.6 | 0.7329 |
| Fasting insulin mcU/mL | 34.2 ± 33.6 | 25.4 ± 13.9 | 0.4611 |
| BMI Z score | 2.1 ± 0.7 | 2.3 ± 0.7 | 0.196 |
*
statistically significant difference
1
Data are reported as median (inter-quartile range: 25th percentile, 75th percentile) if they required a non-parametric test for comparisons. Otherwise, they are mean ± standard deviation.