Table 2.
Clinical characteristics of CS patients with advanced or normal/delayed bone age.
| Advanced Bone age Z-score (n=26) | Normal/Delayed Bone age Z-score (n=98) | P-value | |
|---|---|---|---|
| Chronologic age at time of pre-surgery bone age | 9.9 ± 2.5 | 12.3 ± 3.5 | 0.0001* |
| Duration of symptoms (months) | 36.7 ± 25.5 | 29.4 ± 21.1 | 0.1150 |
| Height SDS | −0.3 ± 1.1 | −1.3 ± 1.3 | 0.0005* |
| Breast tanner stage (females) | 3.0 (1.0, 4.0) | 3.0 (2.0, 5.0) | 0.0679 |
| Testicular volume by Prader orchidometer (males) | 6.5 (6.0, 8.0) | 8.5 (4.5, 20.0) | 0.3327 |
| ACTH, pg/mL | 52 ± 69 | 39 ± 33 | 0.5367 |
| IGF-1 Z-score | 0.7 ± 1.8 | −0.6 ± 1.5 | 0.0004* |
| DHEA-S, μ g/ dL | 206±212 | 189 ± 192 | 0.5117 |
| Normalized ratio of mean for age and sex DHEA-S | 3.2±2.8 | 1.5±1.3 | 0.0001* |
| DHEA, ng/dL | 566 ± 622 | 457 ± 445 | 0.5973 |
| Normalized ratio of mean for age and sex DHEA | 2.9±2.6 | 1.6±1.5 | 0.0054* |
| Androstenedione, ng/dL | 140 ± 95 | 144±119 | 0.8382 |
| Normalized ratio of mean for age and sex Androstenedione | 4.2±3.0 | 2.8±4.9 | 0.0010* |
| Estradiol, pg/mL | 25 ± 42 | 24 ± 32 | 0.4574 |
| Normalized ratio of mean for age and sex Estradiol | 1.8±1.1 | 1.3±1.1 | 0.016* |
| Testosterone, ng/dL | 32 ± 36 | 76 ± 139 | 0.0553 |
| Normalized ratio of mean for age and sex Testosterone | 1.8±1.4 | 1.1±1.1 | 0.0256* |
| UFC, μ g/24 hr | 206±201 | 343 ± 355 | 0.0598 |
| Midnight cortisol, μ g/dL | 17.3 ± 10.9 | 20.6 ± 15.5 | 0.2623 |
| Fasting insulin mcU/mL | 47.0±53.2 | 28.5±19.6 | 0.0651 |
| BMI Z score | 2.4±0.5 | 2.0±0.7 | 0.0146* |
*
statistically significant difference