Table 3.
Reported bone age in pediatric patients with Cushing syndrome over the years
| Reference | Age Median (range) | Sample size | Diagnostic Method | Definition of advanced BA | Definition of delayed BA | Bone Age % (n/N) | ||
|---|---|---|---|---|---|---|---|---|
| Normal | Delayed | Advanced | ||||||
| Hauffa et al 1984 (18) | 14.6 (10.4-18.8) | 10 | Greulich and Pyle | BA-CA>1 yr | BA-CA<-1 yr | 20% (2/10) | 80% (8/10) | 0 |
| Magiakou 1994 (13) | 14 (4-20) | 37 | Greulich and Pyle | BA Z score ≥ 2SD | BA Z score ≤-2SD | 81% (30/37) | 11% (4/37) | 8% (3/37) |
| Lebrethon 2000 (2) | 13.7 (6.8-17.6) | 10 | TW2RUS | BA-CA>1 yr | BA-CA<-1 yr | |||
| Davies 2005 (1) | 12.2 (6.4-16.6) | 14 | TW2RS | BA-CA>1 yr | BA-CA<-1yr | 57% (8/14) | 43% (6/14) | 0 |
| Peters et al 2007 (15) | 12.1 (5.8-17.4) | 17 | TW3 RUS | BA-CA >0 | BA-CA <0 | 0 | 88% (15/17) | (12%) 2/17 |
| BA-CA>1 yr | BA-CA<-1 yr | 29% (5/17) | 71% (12/17) | 0 | ||||
| Achayra et al 2010 (14) | 14.8 (9-19) | 48 | Greulich and Pyle | BA-CA>0 | BA-CA<0 | 27% (13/48) | 73% (35/48) | 0 |
| BA-CA>1 yr | BA-CA<-1 yr | 46% (22/48) | 54% (26/48) | 0 | ||||
| Present study 2013 | 12 (2-18) | 124 | Greulich and Pyle | BA-CA>1 yr | BA-CA<-1 yr | 65% (81/124) | 9% (11/124) | 26% (32/124) |
| BA Z score ≥ 2SD | BA Z score ≤-2SD | 76% (94/124) | 3% (4/124) | 21% (26/124) | ||||