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Structures of selected bioflavonoids. Adapted from (Bandele and Osheroff, 2007). Flavones, flavonols, and isoflavones are shown, and the ability of each to enhance topoisomerase II-mediated DNA cleavage is indicated as >8-fold (+++), 6- to 8-fold (++), 3- to 6-fold (+), 2- to 3-fold (+/−), or <2-fold (−) over baseline.
