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. Author manuscript; available in PMC: 2014 Mar 24.
Published in final edited form as: Allergy. 2011 May 10;66(9):1193–1200. doi: 10.1111/j.1398-9995.2011.02614.x

Figure 5. ADAM10 inhibition also blocks the inflammatory response in the lung tissue.

Figure 5

The lungs from mice where asthma had been induced using Model A, where fixed and sectioned as explained in the Material and Methods. The sections were then de-paraffinized and stained with H&E. Larger photomicrographs are 10x with select inserts from areas showing obvious inflammation at 100x. (A) Photomicrographs using lungs from ADAM10 -/- mice or (B) their littermate controls. (C) Photomicrographs using lungs from C57B/6 that received INCB008765 throughout the induction of asthma or (D) DMSO control lungs. Photos shown are representative from experiments using 4 mice per group.