Figure 2. Screen to identify compounds preventing growth of wild type and BCR-ABL^MUTANT Ph+ ALL cells in the presence of IL-7.

Several hundred validated hits were identified. The hits are shown as a graph with clustering hits using ATC therapeutic classification (http://www.whocc.no/atc/structure_and_principles/). A single compound can be represented more than once because of multiple therapeutic indications, as is the case for the corticosteroids (highly active clusters in A, C, D, H, R, and S). This demonstrates that the active compounds come from drugs used to treat many indications. See Supplemental materials and methods and Supplementary Figure S11 for details on clustering methodology and analysis.