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. Author manuscript; available in PMC: 2015 Feb 15.
Published in final edited form as: Bioorg Med Chem. 2014 Jan 3;22(4):1441–1449. doi: 10.1016/j.bmc.2013.12.056

Table 2.

Anti-proliferative Activities of compounds 69–74, 76–79, 81, 83, 85, 86.

graphic file with name nihms560377u3.jpg
Entry X R SKBr3 (IC50, μ M) MCF-7 (IC50, μ M) PC3 MM2 (IC50, μ M) LNCap (IC50, μ M) 253JB-V (IC50, μ M)
69 CH H 38.1±2.2 25.7±3.7 NT NT NT
70 N OH 56.8±10.1 11.87±0.72 NT NT NT
71 N OCH2CH3 13.5±1.13 13.8±0.82 6.05±1.9 4.71±2.4 NT
72 N OCH2(CH2)2CH3 8.174±0.22 11.27±0.53 5.487±1.1 3.768±0.2 NT
73 N OCH2CH2Ph >100 77.41±5.4 29.76±2.5 22.52±8.9 NT
74 N H 9.1±0.12 10.30±0.17 NT NT NT
76 N O-a 1.13±0.02 2.09±0.31 3.95±0.04 1.798±0.0 NT
77 N O-d 0.21±0.04 0.41±0.04 0.68±0.2 0.40±0.19 NT
78 N O-f 1.02±0.21 1.41±0.03 1.41±0.01 1.67±0.07 1.12±0.40
79 N O-cyclohexyl 26.40±4.2 44.14±2.7 14.12±1.3 13.20±0.0 7.42±0.1
81 N O-g 0.54±0.24 0.72±0.41 1.78±0.4 1.88±0.16 1.79±0.07
83 N O-b 4.58±0.34 5.45±1.1 2.08±0.2 5.49±5.6 0.73±0.7
85 N O-c 0.12±0.04 0.56±0.12 1.33±0.36 1.26±0.07 0.99±0.01
86 N O-h 0.56±0.21 1.21±0.39 1.54±0.31 2.39±0.77 1.89±0.09